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Can Melatonin Reverse Brain Age?

We do the thinking so you don’t have to.

There is sufficient info out there on how melatonin is beneficial to longevity.

Melatonin for Longevity

Melatonin is said to activate sirtuins and AMPK, both of which proteins involved in various mechanisms – DNA repair, reducing oxidative stress, enhanced metabolism and preventing inflammation – that promote longevity. Thus, melatonin supplements are said to be gaining momentum for fighting ageing and health promotion.

We know that Melatonin does facilitate longevity. The question is: “Can Melatonin reverse the ageing brain?”

Melatonin for Brain Health

Let’s use the context of Alzheimer’s disease (AD) to further understand how melatonin promotes brain health. 

Lack of brain-derived neurotrophic factor (BDNF), a type of protein, is said to be one of the causes for AD. BDNF is important because it ensures neuronal survival and growth, and serves as a neurotransmitter modulator, primarily in the cortex and hippocampus of the brain. Without BDNF, beta-amyloid plaques and tau tangles would form – both of which are made of “bad proteins” that disrupt proper synaptic function. Hence, cognitive function is impaired as a result of low BDNF!

Chronic inflammation is another key characteristic of AD. Chronic inflammation is the case whereby microglia – the immune cells in the brain – are constantly being activated to produce inflammatory cytokines, due to the deposition of beta-amyloid plaques and hyperphosphorylated tau tangles. These cytokines reduce the production of BDNF, leading to a vicious cycle. 

Here’s where melatonin acts as the hero. Melatonin binds to MT1 and MT2 receptors, activating the cAMP-PKA pathway, thereby blocking the action of cytokines. In this way, melatonin contributes to increased production of BDNF.

TLDR: Melatonin prevents inflammation in brain cells, thereby indirectly preventing brain diseases such as Alzheimer’s.

Melatonin Supplements

We have spent some time putting together a list of different melatonin supplements that you can chose from. We compare the prices and the pros and cons for you in this article 9 Best Melatonin Supplements To Choose From.

Lack of brain-derived neurotrophic factor (BDNF), a type of protein, is said to be one of the causes for AD. BDNF is important because it ensures neuronal survival and growth, and serves as a neurotransmitter modulator, primarily in the cortex and hippocampus of the brain. Without BDNF, beta-amyloid plaques and tau tangles would form – both of which are made of “bad proteins” that disrupt proper synaptic function. Hence, cognitive function is impaired as a result of low